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Your Brain's 400 Miles of Blood Vessels: A Conversation with Dr. Jason Hinm

The tiny vessels that keep your white matter healthy, the new tests that can spot trouble years early, and what you can do about it now

Your brain has about 400 miles of blood vessels running through it. Most of them are too small to see on any scan we have.

Dr. Jason Hinman is a professor of neurology and a vascular neurologist at UCLA, and those tiny vessels are what his lab studies. They feed the brain’s white matter, the wiring that connects one brain region to another. Damage to them shows up alongside Alzheimer’s disease in at least half of the people who have it.

We talked with Jason about new tests that can catch that damage years early, the signs standard memory tests miss, and what you can do about it, starting with blood pressure and exercise.

In this episode, we cover:

  • What the brain’s blood vessels do besides deliver oxygen

  • Why the tiny vessels are key to white matter health

  • Blood pressure control and the brain

  • Blood tests for brain health

  • New MRI methods that could spot changes years early

  • Early signs that standard memory tests miss

  • How much exercise the brain needs

  • Is hard exercise safe for the brain?

  • LDL cholesterol and the brain’s blood vessels

  • Metabolic syndrome, GLP-1 drugs, and the CRP test for inflammation

  • Lowering side-effect risk on the new anti-amyloid drugs for Alzheimer’s

  • and more!

Learn more about Jason’s work at the Hinman Lab: https://www.hinmanlabucla.org/

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